There is a twitter thread discussing the results of the trial by one of the co-investigators - Professor Jon Stone HERE

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We would also like to share our recent publications relating to the study and an infographic summarising the studies below:

 

Study protocol:

https://doi.org/10.1186/s12883-015-0350-0 

 

Statistical and economic analysis plan:

https://doi.org/10.1186/s13063-017-2006-4

 

Characteristics of CODES baseline sample seen by neurologists:

https://doi.org/10.1111/epi.16350

 

Characteristics of CODES baseline sample seen by psychiatrists and randomised in to the trial:

https://doi.org/10.1017/S0033291720001051

 

Predicting first attendance at psychiatry appointments:

https://doi.org/10.1016/j.seizure.2019.11.014

 

Qualitative studies:

Psychiatrists views: http://dx.doi.org/10.1136/bmjopen-2018-026493

 

Psychotherapists views; https://doi.org/10.1016/j.yebeh.2020.106943

 

Neurologists views:  https://doi.org/10.1016/j.seizure.2019.05.020

 

Participants views: https://doi.org/10.1016/j.yebeh.2020.107230

 

Study looking at the performance of the PHQ-9 versus interview for depression in CODES : https://doi.org/10.1016/j.jpsychores.2021.110487

 

HTA report: https://doi.org/10.3310/hta25430 

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Six month outcomes:   https://doi.org/10.1016/j.seizure.2022.01.016

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Moderators and predictors of outcome - https://doi.org/10.1016/j.jpsychores.2022.110921 

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Mediators of treatment effect - https://doi.org/10.1017/S0033291723003665

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Overview and reflections - ​​http://dx.doi.org/10.1136/bmjno-2024-000659.

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The figure below is Figure 2 from the overview and reflections paper.

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Summary of key data from the CODES trial. This figure includes still images taken from an animated video created by Science Animated (sciani.com). The originals are available at www.codestrial.org and https://www.youtube.com/ watch?v=pUFKbYH7BcQ. CBT, cognitive behavioural therapy; CGI, Clinical Global Impression of Change; CODES, COgnitive behavioural therapy versus standardised medical care for adults with Dissociative non- Epileptic Seizures; CORE- 10, Clinical Outcomes in Routine Evaluation 10; EQ- 5D- 5L, European Quality of Life 5 Dimensions 5 Levels; GAD- 7, 7- item Generalised Anxiety Disorder Assessment; NICE, National Institute for Health and Care Excellence; PHQ, Patient Health Questionnaire; QALY, quality adjusted life year; SF- 12v2 MCS, 12- item Short Form Survey version 2 Mental Component Summary score; SF- 12v2 PCS, 12- item Short Form Survey version 2 Physical Component Summary score; SMC, standardised medical care; WSAS, Work and Social Adjustment Scale. “© Goldstein et al 2024. BMJ Neurology Open

2024;6:e000659. doi:10.1136.  This figure is licensed under the Creative Commons Attribution CC BY 4.0 licence. To view a copy of this licence visit https://creativecommons.org/licenses/by/4.0/